CASE 1 : CARNITINE DEFICIENCY
PROBLEM STATEMENT:
A teenage boy was brought to a hospital as he complaints that he always get too tired when asked to participate in the any of school activities. The doctor found muscle weakness in the boy’s arms and legs. From the muscle biopsy, the lab pathologist found that greatly elevated amount of triglycerides esterified with primary long fatty acid chain. They also found significant presence of lipid vacuoles in the muscle biopsy.
What causes this symptoms?
A teenage boy was brought to a hospital as he complaints that he always get too tired when asked to participate in the any of school activities. The doctor found muscle weakness in the boy’s arms and legs. From the muscle biopsy, the lab pathologist found that greatly elevated amount of triglycerides esterified with primary long fatty acid chain. They also found significant presence of lipid vacuoles in the muscle biopsy.
What causes this symptoms?
CASE 2 : CHOLESTEROL ( TANGIER DISEASE )
PROBLEM STATEMENT:
A form 6 students share a news with you. I am shocked when I look at my blood test result. My blood total cholesterol is more than 300 mg/dL, the LDL cholesterol is be more than 220 mg/dL but my triglyceride levels tend to be normal, which are below 150 mg/dL. I am still young! I have a healthy life because I do not want to be like my mother who is having hypercholestrol. Am I having Tangier’s disease.
Explain him the condition and things he can do to help himself. Explain what is Tangier’s disease too.
A form 6 students share a news with you. I am shocked when I look at my blood test result. My blood total cholesterol is more than 300 mg/dL, the LDL cholesterol is be more than 220 mg/dL but my triglyceride levels tend to be normal, which are below 150 mg/dL. I am still young! I have a healthy life because I do not want to be like my mother who is having hypercholestrol. Am I having Tangier’s disease.
Explain him the condition and things he can do to help himself. Explain what is Tangier’s disease too.
CASE 3 : FLUOROACETATE TOXIC
PROBLEM STATEMENT:
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. His next of kin told the triage that he accidentally swallow a rodent poison, which he thought it is some kind of candy placed on the kitchen table. The lab results were positive for fluoroacetate toxic.
As a pathology researcher, you have to explain the whole situation (biochemically) to a bunch of industrial trainees in your pathology lab.
A man was found having nausea, vomiting and abdominal pain, sweating, confusion and agitation follow. His next of kin told the triage that he accidentally swallow a rodent poison, which he thought it is some kind of candy placed on the kitchen table. The lab results were positive for fluoroacetate toxic.
As a pathology researcher, you have to explain the whole situation (biochemically) to a bunch of industrial trainees in your pathology lab.
CASE 4 : LACTIC ACIDOSIS
PROBLEM STATEMENT:
Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood (acidosis) accompanied by the build up of lactate, especially L-lactate, and is considered a distinct form of metabolic acidosis. Lactic acidosis is characterized by lactate levels >5 mmol/L and serum pH <7.35.
In a Young Biochemist Association Forum, you are invited to explain about the condition and how DCA could treat it.
Lactic acidosis is a physiological condition characterized by low pH in body tissues and blood (acidosis) accompanied by the build up of lactate, especially L-lactate, and is considered a distinct form of metabolic acidosis. Lactic acidosis is characterized by lactate levels >5 mmol/L and serum pH <7.35.
In a Young Biochemist Association Forum, you are invited to explain about the condition and how DCA could treat it.